Date seeds have also been shown to exert in vitro and in vivo antioxidant effects. Keeping the balance between the production of ROS and their catabolism by antioxidants is a critical mechanism in preventing damage from oxidative stress.
Therefore, supplementation with antioxidants has been used to prevent STZ-induced reproductive dysfunctions. Although date seeds are readily available, few studies have been undertaken to prove their antidiabetic and antioxidative activity.