We believe that the lack of further reduction in 8-epi-PGF2 concentrations in women after orange juice consumption might have been because concentrations of 8-epi-PGF2 were significantly lower
and vitamin C concentrations significantly higher in women than in men throughout the study. Other studies also reported changes in 8-isoprostane concentrations after supplementation with vitaminC, vitamin E, or both (51–53).