Received 23 February 1996; Accepted 14 June 1998
MUTTRAY, A., V. WOLTERS, D. JUNG, AND J. KONIETZKO.
Effects of high doses of toluene on color vision
.
NEUROTOXICOL TERATOL
21
(1) 41–45, 1999.—High exposure to toluene may cause optic neuropathy and retinopathy,
both associated with dyschromatopsia. Another solvent, ethanol, is known to induce acute blue–yellow dyschromatopsia.
This study investigated the acute effects of high doses of toluene on color vision. Eight male printshop workers were examined
before and after cleaning printing containers with pure toluene. After cleaning, concentrations of toluene in blood were
between 3.61 and 7.37 mg
/
l. Color vision was tested with the Farnsworth panel D-15 test, the Lanthony desaturated panel
D-15 test, and the Standard Pseudoisochromatic Plates part 2. For control of possible acute effects, eight workers of a metalworking
factory without any neurotoxic exposure were tested according to the same procedure. Acute exposure to toluene
did not cause impairment of color vision. However, statistical power is limited due to the small number of exposed subjects.
Color vision of the printshop workers tested before cleaning was slightly impaired (statistically not significant) when compared
with unexposed subjects. © 1999 Elsevier Science Inc. All rights reserved.
Toluene Printer Occupational exposure Color vision
Received 23 February 1996; Accepted 14 June 1998
MUTTRAY, A., V. WOLTERS, D. JUNG, AND J. KONIETZKO.
Effects of high doses of toluene on color vision
.
NEUROTOXICOL TERATOL
21
(1) 41–45, 1999.—High exposure to toluene may cause optic neuropathy and retinopathy,
both associated with dyschromatopsia. Another solvent, ethanol, is known to induce acute blue–yellow dyschromatopsia.
This study investigated the acute effects of high doses of toluene on color vision. Eight male printshop workers were examined
before and after cleaning printing containers with pure toluene. After cleaning, concentrations of toluene in blood were
between 3.61 and 7.37 mg
/
l. Color vision was tested with the Farnsworth panel D-15 test, the Lanthony desaturated panel
D-15 test, and the Standard Pseudoisochromatic Plates part 2. For control of possible acute effects, eight workers of a metalworking
factory without any neurotoxic exposure were tested according to the same procedure. Acute exposure to toluene
did not cause impairment of color vision. However, statistical power is limited due to the small number of exposed subjects.
Color vision of the printshop workers tested before cleaning was slightly impaired (statistically not significant) when compared
with unexposed subjects. © 1999 Elsevier Science Inc. All rights reserved.
Toluene Printer Occupational exposure Color vision
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