3.4. Morphological studies on rectal tissue
Fig. 10b and c show photomicrographs of rectal mucosa taken from rabbits 6 h after rectal administration of 2% w/w xyloglucan gels with and without added indomethacin. Comparison with photomicrographs of rectal mucosa from control rabbits (Fig. 10a) shows no detectable tissue damage resulting from exposure to a single dose administration of gel. Further studies of the effect of repeated administration are required to more fully establish the suitability of this vehicle for rectal administration.