Male adult Sprague–Dawley rats (4 months old, 250 to 280 g) were allowed to acclimatize for at least 7 days prior to experimentation. The rats were randomly divided into the following 4 groups (n =10): sham, middle cerebral artery occlusion (MCAO, vehicle), low-(MCAO + ICA-L) and high-dose ICA-treatment (MCAO + ICA-H)groups. Low- and high-dose ICA-treated groups were administered with ICA at doses of 10 and 30 mg/kg, respectively, by gavage twice per day for 3 consecutive days, while sham and MCAO rats were administered volume-matched normal saline, instead. Then, test with Neurological examinations ,Infarct size measurement and Western blot analysis.