In the study, all patients aged 50 or under were men. It has been well established that male gender is a risk factor of CAD [24], [25], and previous studies have shown that men with ACS are more likely to have ruptured plaques, whereas women are more likely to present with plaque erosion, suggesting that the mechanism of ACS development in men and women differs [24]. For example, it has been speculated that estrogen might contribute to delaying the plaque development, stabilizing the existing plaques, and preventing plaque rupture in women [25].
In the study, all patients aged 50 or under were men. It has been well established that male gender is a risk factor of CAD [24], [25], and previous studies have shown that men with ACS are more likely to have ruptured plaques, whereas women are more likely to present with plaque erosion, suggesting that the mechanism of ACS development in men and women differs [24]. For example, it has been speculated that estrogen might contribute to delaying the plaque development, stabilizing the existing plaques, and preventing plaque rupture in women [25].
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