Main results
Five RCTs met the inclusion criteria. The maximum number of studies compared in the meta-analysis was three (31 on oxygen versus
32 control participants), because all included studies did not measure the same outcomes. When two studies were pooled, statistically
significant improvements of oxygen-supplemented exercise training were found in constant power exercise time , WMD 2. 68 minutes
(95% CI 0. 07 to 5. 28 minutes). Supple mental oxygen increased the average exercise time from 6 to 14 minutes; the control intervention
increased average exercise time from 6 to 12 minutes. Constant power exercise end-of -test Borg score (on a scale from 1 to 10) also
showed statistically significant improvements with oxygen-supplemented exercise training, WMD -1. 22 units (95% CI -2. 39 to -0. 06).
One study showed a significant improvement in the change of Borg score after the shuttle walk test, by -1. 46 units (95% CI -2. 72 to -0. 19). There were no significant differences in maximal exercise outcomes, functional exercise outcome s (six-minute walk test), shuttle
walk distance , health -related quality of life or oxygenation status. According to the GRADE system most outcomes were rated as low
quality because they were limited by study quality
Main resultsFive RCTs met the inclusion criteria. The maximum number of studies compared in the meta-analysis was three (31 on oxygen versus32 control participants), because all included studies did not measure the same outcomes. When two studies were pooled, statisticallysignificant improvements of oxygen-supplemented exercise training were found in constant power exercise time , WMD 2. 68 minutes(95% CI 0. 07 to 5. 28 minutes). Supple mental oxygen increased the average exercise time from 6 to 14 minutes; the control interventionincreased average exercise time from 6 to 12 minutes. Constant power exercise end-of -test Borg score (on a scale from 1 to 10) alsoshowed statistically significant improvements with oxygen-supplemented exercise training, WMD -1. 22 units (95% CI -2. 39 to -0. 06).One study showed a significant improvement in the change of Borg score after the shuttle walk test, by -1. 46 units (95% CI -2. 72 to -0. 19). There were no significant differences in maximal exercise outcomes, functional exercise outcome s (six-minute walk test), shuttlewalk distance , health -related quality of life or oxygenation status. According to the GRADE system most outcomes were rated as lowquality because they were limited by study quality
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