Prokinetic drug may be given to patient with alterd gastric emptying. Erythromycin and metoclopramide are two prokinetic drug that have been studied in patient in th ICU receiving enteral nutrition. Treatment with erythromycin was more effective than metoclopramide, but the effectiveness of both treatments declined rapidly over time. In patients who failed monotherapy, rescue combination therapy was highly effective (day maintained its effectiveness for the study duration (day 6 67%). High pretreatment gastric residual volume was associated with poor response to prokinetic therapy.