Objective. An effective program for preventing metabolic diseases through lifestyle modification is
urgently needed. We investigated the effects of the Life Style Modification Program for Physical Activity and
Nutrition program (LiSM10!®) on metabolic parameters in middle-aged male Japanese white-collar workers.
Methods. One hundred and one male office workers, 30 to 59 years of age, with metabolic syndrome risk
factors, were randomly allocated into no-treatment control (n= 49) and LiSM intervention (n= 52) groups.
The LiSM group attended individualized assessment and collaborative goal setting sessions based on food
group intake and physical activity, followed by two individual counseling sessions with a registered dietitian
and physical trainer, and received monthly website advice during the 4-month period from December 2006
to May 2007, in Tokyo, Japan. They were encouraged to enter current targeted food intakes and pedometer
data on self-monitoring websites during the entire study period.
Results. Habitual food group intakes changed significantly in the LiSM group, showing improvements in 14
anthropometric and biochemical parameters contributing to inter-group differences in body weight, body mass
index, fasting plasma glucose, insulin and homeostasis model assessment of insulin resistance changes (pb0.01).
Conclusion. The LiSM10!® program effectively improved insulin resistance-related metabolic parameters in
middle-aged male white-collar workers.