We then injected the thermal-treated Ara h 2 into the mice.
The content of specific IgE, histamine, and Th2 type cytokines,
including IL-4, 5, and 13, were all up-regulated, whereas IgG2a
and Th1 type cytokines, such as IFN-c, were down-regulated
(Fig. 4C and D), suggesting that thermal-treated Ara h 2 could trigger
varying degrees of anaphylaxis in mice.