These neuropeptides
may take part in neurogenic inflammation (plasma protein extravasation and vasodilatation) of the intracranial
vasculature and peripheral and central sensitization of the trigeminal system. The results of human
clinical studies are discussed with regard to the alterations in these neuropeptides in the plasma, saliva and cerebrospinal
fluid during or between migraine attacks, and the therapeutic possibilities involving migrainerelated
neuropeptides in the acute and prophylactic treatment of migraine headache are surveyed.