The response to myotrauma has been likened to the acute
inflammatory response to infection. Once damage is perceived
by the body, neutrophils migrate to the area of microtrauma
and agents are then released by damaged fibers that attract
macrophages and lymphocytes.Macrophages remove cellular
debris to help maintain the fiber’s ultrastructure and produce
cytokines that activate myoblasts, macrophages and lymphocytes.
This is believed to lead to the release of various growth
factors that regulate satellite cell proliferation and differentiation
(182,187).