Long-term exposure to copper can cause irritation of the nose, mouth and eyes and it causes headaches, stomachaches, dizziness, vomiting and diarrhea. Intentionally high uptakes of copper may cause liver and kidney damage and even death. Whether copper is carcinogenic has not been determined yet.
There are scientific articles that indicate a link between long-term exposure to high concentrations of copper and a decline in intelligence with young adolescents. Whether this should be of concern is a topic for further investigation.
Industrial exposure to copper fumes, dusts, or mists may result in metal fume fever with atrophic changes in nasal mucous membranes. Chronic copper poisoning results in Wilson’s Disease, characterized by a hepatic cirrhosis, brain damage, demyelization, renal disease, and copper deposition in the cornea.