Chlorophyll and their water-soluble salts (chlorophyllin) are constituent of the human diet and have been found to be effective anticarcinogen in several animal models. Studies have further revealed that chlorophyllin intervention can reduce aflatoxin-DNA adduct in a population at high risk of developing liver cancer.Selenium might be a cancer chemopreventive component in certain forms through the effect of antioxidant protection,enhanced carcinogen detoxification, enhanced immune surveillance, modulation of cell proliferation, inhibition of tumor cell invasion, and inhibition of angiogenesis.Vitamin A, vitamin C, vitamin E, b-carotene, organic acid,and vegetable oil can reduce free radical accumulation, increase multi-enzyme activities, reduce GSH and ATP levels, and maintain lipids and calcium. Recently, liposoluble vitamins, such as vitamins A and E, have attracted attention because of their effects on the mitochondrial membrane potential to stimulate cytochrome c release and caspase-3/and -7 activation in rat liver mitochondria. Thiamine, vitamin B2, and Zn can enhance the defense capability of the immune system