Epidemiology
Incidence is 1-2 per 100,000 population per year in the UK and the USA.[1]
Most cases occur in those aged over 60 years.
There is a high incidence of cholangiocarcinoma in Southeast Asian countries, due to chronic endemic parasitic infection with liver flukes.
In Japan and Israel the incidence is much higher at 5.5 and 7.3 cases per 100,000 people per year.[1]
The incidence of intrahepatic cholangiocarcinoma is increasing and the incidence is estimated as 0.9-1.3/100,00 for males and 0.4-0.7/100,000 for females. Intrahepatic cholangiocarcinoma accounts for 10-15% of primary liver cancer.[2]