The teleost Ig are limited to mainly a IgM tetramer of
approximately 800 kD and no definitive evidence of Ig
diversity has been demonstrated in fish. It has been long
considered that fish Ig have a restricted profile of isotopes
as a result of a phylogenetic simplicity. This seems consistent
with evolutionary data, as fish is the first group that shows
antibody activity and therefore a simple profile of one Ig
appears in this group. Later on, evolution resulted in the
generation of complexity and a increasing number of Ig
isotypes in amphibians, reptiles and birds, being maximal
in the higher vertebrates, i.e., mammals. It is then assumed
that the response of fish to immune challenge is mainly
based on the innate immune response
The teleost Ig are limited to mainly a IgM tetramer of
approximately 800 kD and no definitive evidence of Ig
diversity has been demonstrated in fish. It has been long
considered that fish Ig have a restricted profile of isotopes
as a result of a phylogenetic simplicity. This seems consistent
with evolutionary data, as fish is the first group that shows
antibody activity and therefore a simple profile of one Ig
appears in this group. Later on, evolution resulted in the
generation of complexity and a increasing number of Ig
isotypes in amphibians, reptiles and birds, being maximal
in the higher vertebrates, i.e., mammals. It is then assumed
that the response of fish to immune challenge is mainly
based on the innate immune response
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