If you make the comparison, with respect to quality, then you won't find any difference, as chemically they are similar. The fire, brilliance and unique optical qualities of natural diamonds are exactly matched by synthetic diamonds. The only difference is in colors and flaws shown by natural diamonds that cannot be mimicked in synthetic ones. In spite of this, even experienced jewelers find it difficult sometimes to distinguish between synthetic and natural diamonds. There is advanced equipment available, which can easily distinguish between the two types by checking the inclusions and internal composition of the diamonds. Synthetic diamonds have distinct metal inclusions, which natural diamonds are devoid of.