The iCELLis 500 can offer a fixed-bed with a MC surface of 500 m2 and a volume of 25 L (a bioreactor working volume of 70 L). Based on our experimental data with insect cells culture in the fixed-bed iCELLis nano (cell seeding of 1.7×1E4 cells/cm2 or 0.7×1E9 total cells and Xmax of 5.8×
1E5 cells/cm2 or 2.3×1E10 total cells with a rRVGP productivity of 5.3 mg) we can rationally predict an iCELLis 500 cell culture with cells recovered from approximately 4 iCELLis nano for a iCELLis 500 productivity of 712 mg of rRVGP with a Xmax of 2.9×1E12 cells.