Insulin resistance :DM-lean, obese
:Non-DM-lean, obese
-lean diabetics = lean non-diabetics
-obese type 2 DM >> obese non-DM
-insulin resistance of type 2 DM is specific of the diabetic state.
Type 2 DM :
-Hepatic glucose production is less reduced.
-Peripheral glucose utilization is less stimulated in response to insulin.
-Liver & peripheral tissues are resist for insulin.