6. Breeding
1. Breeding must be justified on the animal use protocol. Need is based on scientific need or lack of availability of commercial sources, not on cost or convenience.
2. Standard breeding protocols should be followed. Attention should be paid to maintenance of genetic homogeneity (inbred animals) or heterogeneity (outbred animals). Genetic monitoring may be necessary for large or long-term breeding programs.
3. Cage space requirements must be closely monitored for breeding animals. Because many laboratory species have large litters and rapid growth rates, usually no more than one breeding pair per cage is appropriate. Animals should be weaned before puberty and separated into same-sex groups based on adult maximum weights