Finally, several previous studies have investigated the
effect of image processing on calcification detection.
One small study found no significant difference in detection
due to image processing. Three other studies compared
digital images with different image processing to
screen-film imaging, but did not compare image processing
software directly. The remaining study by Zanca et al.
used unprocessed clinical images into which simulated calci-
fication clusters were inserted. This study found significant
differences in detection between several image processing
algorithms.