Supportive measures: these play a critical role in the inpatient management of patients in withdrawal. Frequent re-evaluation of the patient is of paramount importance since the various withdrawal syndromes may coexist with or be mimicked by other conditions. Infection, trauma, metabolic derangements, drug overdose, hepatic failure, or gastrointestinal bleeding frequently complicate the clinical syndrome. When faced with altered sensorium without a definite cause it may be necessary to perform extensive testing, such as lumbar puncture and CT scan, to confidently exclude other diagnostic considerations, especially when patients present with fever in addition to a withdrawal syndrome