Shock waves can cause significant cytotoxic effects in tumor cells and tissues both in vitro and in vivo. However,
understanding the mechanisms of shockwave interactionwith tissues is limited.We have studied in vivo effects
of focused shock waves induced in the syngeneic sarcoma tumor model using the TUNEL assay, immunohistochemical
detection of caspase-3 and hematoxylin–eosin staining. Shockwaveswere produced by amultichannel
pulsed-electrohydraulic discharge generator with a cylindrical ceramic-coated electrode. In tumors treated with
shock waves, a large area of damaged tissue was detected which was clearly differentiated from However,
understanding the mechanisms of shockwave interactionwith tissues is limited.We have studied in vivo effects
of focused shock waves induced in the syngeneic sarcoma tumor model using the TUNEL assay, immunohistochemical
detection of caspase-3 and hematoxylin–eosin staining