between conserved complementary nucleotide sequences
at the 3 and 5 ends of each RNA genome segment. The
family derives its name from the presence within virions
of cellular ribosomes, which, under thin-section electron
microscopy, resemble grains of sand (arena, sand). The
biological significance of this distinctive and unusual prop-
erty remains uncertain. The genome of arenaviruses con-
sists of two segments of single-stranded RNA, designated
large (L) and small (S), approximately 7.5 and 3.5 kb in
size, respectively. Virions may contain multiple copies of
the two genome segments, often with more copies of the S
RNA segment.
Most of the genome is of negative sense, but the
5 half of the S segment and the 5 end of the L seg-
ment are of positive sense; the term ambisense is used to
describe this unusual genome arrangement, which is also
between conserved complementary nucleotide sequences
at the 3 and 5 ends of each RNA genome segment. The
family derives its name from the presence within virions
of cellular ribosomes, which, under thin-section electron
microscopy, resemble grains of sand (arena, sand). The
biological significance of this distinctive and unusual prop-
erty remains uncertain. The genome of arenaviruses con-
sists of two segments of single-stranded RNA, designated
large (L) and small (S), approximately 7.5 and 3.5 kb in
size, respectively. Virions may contain multiple copies of
the two genome segments, often with more copies of the S
RNA segment.
Most of the genome is of negative sense, but the
5 half of the S segment and the 5 end of the L seg-
ment are of positive sense; the term ambisense is used to
describe this unusual genome arrangement, which is also
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