degenerative tubule, glomeruli with areas of hemorrhages,
glomerular atropy and picnotic nuclei indicating renal toxicity
(Fig. 3). The root extracts of T. cordifolia at low dose treated rats
shown moderate degenerative changes. Atropic glomeruli
with mild hemorrhages and enlarged renal epithelial cells
were found with the kidney sections in group III rats (Fig. 4). At
high doses (group IV) regenerative changes were observed.
Significant reduction in picnotic nuclei and congestion of
glomeruli were observed (group V) (Figs. 5 and 6).