The longevity curves were plotted using the Kaplan–Meier method
including all available mice at each time point (Baur et al., 2006), and
the Logrank test was applied to compare the distributions of the different
groups. The results from the pathological analysis of the liver were
analyzed using the Kruskal–Wallis test, and significant differences
between treatment groups were further analyzed using the Mann–
Whitney-U test. All other data were analyzed with one-way ANOVA
and significant differences between treatment groups were further
analyzed using the t-test. P-values less than 0.05 were considered to
be statistically significant