5. Conclusion
The present work is significant in three ways. (1) We examined the long-term effect of supplementation of ginger powder on inflammatory markers in patients with knee OA. (2) The study was a double-blind randomized clinical trial, meaning that neither the researchers nor the patients were aware of the content of capsules. (3) The protocol involved a control group that was similar to the GG in all measurements.
It is also important to note the limitation in that the present study did not measure neuronal sensitization, Immunoglobulin G (IgG), Immunoglobulin M (IgM), and did not determine ginger capsule's formulation. Sample attrition resulting from patient withdrawal may be regarded as another limitation of the protocol. Further research into this topic could evaluate the effect of supplementation of 1 g/d ginger capsule on lipid profile, coagulation factors, other inflammatory mediators, and neuronal sensitization. Future research can also consider the effect of 1 g/d ginger capsule on oxidative stress-related parameters.