Biomarkers of exposure are important in toxicology because they are an indicator of chemical exposure that has resulted in absorption into the body.
organophophrphate pesticides share a common mechanism of toxicity, through inhibitory effects on cholinesterase enzymes in the nervous system.
extensive inhibitor of this enzyme leads to accumulation of the neurotransmitter acetylcholine, enhanced stimulation of postaynaptic cholinergic receptors and consequent signs of cholinergic toxicity.one of the most recognized forms of acute toxicity following exposure to organophosphate isautonomic dysfunction,characterized by excessive secretions at parasympathetic end organs (ecobichon,2003).