The learning ability of students in science is improved by socio-scientific decision-making, an important activity that improves a student’s scientific literacy, conceptual understanding, scientific inquiry, attitudes, and social values. The socio-scientific issues must be discussed during science classroom activities in the current state of 21st century skills. This paper expands upon how to enhance socio–scientific decision making in the classroom, presenting a detailed thematic review of socio-scientific decision which is relevant to research studies’ needs, methods, general knowledge claims, and implications. The methods of studies consist of interviewing, class observation, open-ended questions, free writing, audio-tape recorded discussion, and role play. The result is that it can be recommended, taking into account their findings in teaching processes.