In the control cells, we used a glucose concentration of 5 mM,
which is within the normal blood glucose concentration in humans.
Whereas we agree that a 30 mM glucose concentration is higher
than the usual nonfasting glucose level in diabetic patients, this
could be the glucose concentration in some uncontrolled diabetic
patients. Moreover, this relatively high glucose concentration is
used in many published papers, for example, 20
30 mM for vascular smooth muscle cells,
40 mM for endothelial cells,30 mM for cardiomyocytes and hepatocytes, and even higher levels, >100 mM, for peritoneal mesothelial cells.
45 Although EGCG has been reported to have a potent anti-diabetes pronot published in those papers. Pharmacokinetic studies in humans
indicate that the peak plasma concentration after a single oral
dose of EGCG is