Weight loss is associated with substantial health benefits. In this investigation, we highlight that the mode of weight loss influences different physiological pathways with calorie restriction initially targeting the sympathetic nervous system, whereas changes in insulin resistance precede effects on the sympathetic nervous system in subjects partaking in an exercise program
Indeed, the novel findings of this study are that in the D alone group, suppression of high plasma NE followed by reductions in HOMA-IR, weight loss and BP reduction was observed. This contrasted with the EX alone group, where
reduction in HOMA-IR was observed initially followed by suppression of high plasma NE, weight loss and BP reduction. Additionally, in allsubjects, not only the D alone group, changes in plasma NE and HOMA-IR in the acute period of weight loss (4 weeks) were significant determinants of changes in BMI over the 24-week period, suggesting that early reductions on sympathetic nervous activity and insulin resistance might be predictors of subsequent weight loss