Oxygen consumption (VO2) is considered as the gold standard for assessing energy expenditure during an activity [8]. Walking energy consumption is a valid evaluation of walking performance in individuals. Gait disabilities, such as CP and stroke, increase the energy expenditure of walking and the intensity of physical effort with altered walking speeds [9]. Our study was designed to evaluate the effect of a treadmill walking exercise as a mean of improving the energy expenditure of walking and gait efficiency in adults with CP. We also determined improvement in parameters such as gait speed, distance and energy consumption during overground walking or treadmill walking in response to such exercise in ambulatory CP patients.