To validate of feasibility of FMAATPE, the experiments were conducted under the optimum conditions, triplicate results follows as 75.40, 76.50, 75.38 mg/g of extraction yield for total alkaloids, and their mean value and the RSD were also 75.76 mg/gand 2.1%, respectively. The validation results demonstrated that adapting L9(33) orthogonal array scheme could optimize FAATPE conditions even obtain higher yield than PMAE, reducing the time and cost, and improving the performance characteristics.