This paper addresses to what extent mango purée macroscopic properties (consistency) is related to its particle physical properties such as mesoscopic (particle size) and microscopic (morphology) properties. To manipulate mango purée particle sizes, high pressure homogenization (HPH) was used. Commercial fungal and bacterial (cell wall) polysaccharide degrading enzymes without/with HPH (different sequences) were used to understand the contribution of specific (cell wall) polysaccharides and the relevant parameters to consistency changes. The results reflect that, unlike endo-cellulase, pectin methylesterase (PME) together with endo-polygalacturonase (PG), and α-amylase significantly contributed to consistency decrease. HPH only, although largely changing the particle size, did not change the purée consistency, but the combination of HPH with an enzymatic treatment decreased it substantially. Enzymes, while having minimal effect on particle sizes, induced a type-dependent modification of particles’ morphology, showing the accessibility of particle polymers (in addition to the expected serum polymers) to enzymes.