May administer injectable orally
Continuous IV infusion recommended for acute ingestion (ideally within 8-10 hr following ingestion, but may administer if >10 hr)
Intermittent IV infusion may be considered for late presenting or chronic ingestion (more than 10 hr after ingestion)
Oral administration
• May administer injectable orally
• Loading dose: 140 mg/kg PO
• Maintenance dose: 70 mg/kg PO q4hr for 17 doses; repeat if emesis occurs within 1 hr of administration
IV continuous infusion
• Acute ingestion (within 8-10 hr after ingestion)
• Administer as 3 doses
• Loading dose: 150 mg/kg IV; mix in 200 mL of D5W and infuse over 1 hr
• Dose 2: 50 mg/kg IV in 500 mL D5W over 4 hr, THEN
• Dose 3: 100 mg/kg IV in 1000 mL D5W over 16 hr
• >100 kg: No specific studies have conducted; limited data suggest a loading dose of 15,000 mg infused IV over 1 hr, then a first maintenance dose of 5,000 mg IV over 4 hr and a second maintenance dose of 10,000 mg over 16 hr