are bactericidal
broad-spectra antibacterial agents that act especially against gramnegative bacteria; inhibit bacterial growth by interfering with the
enzyme DNA gyrase [4]. Due to their low minimum inhibitory
concentration (MIC) value for most susceptible fish pathogens and
effective systemic distribution in fish when administered orally via
medicated feed, quinolones have been widely used to treat systemic
bacterial infections in fish [5,6]. The antimicrobial spectrum of
norfloxacin makes this drug attractive in veterinary therapy [7].
The aim of this study is to investigate the pharmacokinetics profile
of norfloxacin following single intravenous, oral administration in
healthy goldfish and multiple oral administrations in healthy and
experimentally Aeromonas hydrophilia infected goldfish.