In summary, this study compared the inactivation of spoilage and disease-causing microorganisms in turbulent flowing, UV-C treated young coconut liquid endosperm. Similar with previously reported works, all test organisms were inactivated in the suspending food matrix in a logarithmic-linear, first order kinetics. Results are also in agreement with previous observations that microbial UV-C susceptibility varied within the test organisms, particularly among the tested spoilage organisms. In this current work, the significantly most resistant test organism was determined to be Klebsiella sp., a bacterium isolated from spoiled young coconut liquid endosperm. Among the tested pathogens, the most resistant test organism was identified to be E. coli O157:H7, although its inactivation parameters were not significantly different from S. enterica and L. monocytogenes. Together with previously reported works, these results may serve as baseline information in the establishment of schedules for the UV-C processing of young coconut liquid endosperm, which will ensure safety and shelf-life extension of the commodity. Future studies should focus on the establishment of the D and DUV-C values of the identified resistant organism in a larger scale challenge set up. These inactivation kinetic parameters could be used in the establishment of process schedules with the recommended levels of lethality to ensure quality and safety. The utility of the established process schedules should further be evaluated by measuring their effects on the nutritional and sensory attributes of the finished products.