From the results obtained in this study, it can be concluded that cocoa intake reduces the oxidative stress in macrophages provoked by adjuvant arthritis. This antioxidant effect of cocoa is dependent on the doses employed. Nevertheless, we still need to discover the antioxidant effect of cocoa on joint tissues and to ascertain the relationship between this antioxidant effect and inflammatory markers. Further studies are needed to establish more deeply the role of cocoa, a source of antioxidant flavonoids, as a coadjuvant in the treatment of chronic inflammatory diseases.