Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous hormone, was found in animal and plant kingdom. Melatonin is produced in all vertebrates including human and animal, The secretion of melatonin is occur in the pineal gland which position on the hypothalamus. The function of melatonin is regulation of circadian rhythm, endocrine system, immune system, reproductive and the mechanism of carcinogenesis. There have been evidence indicated that melatonin as an antioxidant, the reduction of melatonin content is effected by disease and oxidative stress. Melatonin is a naturally hormone,