Conclusions
Despite the richness of the findings presented by the authors, a direct and causal link between the observed phenomena and the neuroprotective properties of RVTL is still missing. For example, would inhibition of spine maturation be able to reverse RVTL-induced amelioration of memory performance? Would selective inhibition of Akt and PKC signaling pathways be capable of counteracting the beneficial effects of flavonoid treatment?
Future investigations are required to fully establish a complete and detailed picture of the mechanisms underlying the positive effects of this grape-derived natural compound on brain function. However, one thing is for certain: in a society characterized by an unbalanced life style, stress and fast-food alimentation, a healthy diet is a good move to help improve our brain function. What better place to start than wine — in moderation?