lorophenyl)ethyl]-1H-imidazole. It is used for the treatment of Candida species and dermatophytes.1 Different HPLC methods have been reported for the determination of isocna- zole.2–4 Diflucortolone valerate (Fig. 1b), 6a,9a-difluoro-3,20- dioxo-11b-hydroxy-16a-methylpregna-1,4-dien-21-yl valerate is an anti-inflammatory corticosteroid.1 A HPLC method for determination of diflucortolone valerate is reported in litera- ture.5 Binary mixture of these drugs is used for the treatment of eczematous mycoses.6 Only two methods were reported for the simultaneous determination of these components in