Dietary supplementation with phosphorylated mannans improves growthresponse and modulates immune function of weanling pigsABSTRACT: Phosphorylated mannans derived fromthe yeast cellwall of Saccharomyces cerevisiaemay ben-eficiallymodulate immune function in theweanling pig,possibly providing an alternative to the use of dietarygrowth-promoting antibiotics. Therefore, in this study,32 pigs averaging 19 d of age and 5.7 ± 0.2 kg initialBW were randomly assigned to 16 pens in an environ-mentally controlled nursery to determine the effects ofdietary supplementation with phosphorylated man-nans on growth and immune function. Average dailygain and G:F ratio increased (P < 0.05) when pigs werefed diets supplemented with mannans from d 0 to 14after weaning and in the overall experiment. Percent-age of neutrophils was lower (P < 0.08) and percentageof lymphocytes was higher (P < 0.05) in blood from pigsfed mannans than when pigs were fed the basal diet.Lamina propria macrophages isolated from pigs feddiets containing mannans phagocytosed a greater (P <0.05) number of sheep red blood cells (2.63 ± 0.11) thandid lamina propria macrophages isolated from pigs fedthe basal diet (2.31 ± 0.11). On d 19 after weaning, pigsfed diets supplemented with mannans tended to havea greater (P < 0.10) percentage of CD14+ lamina proprialeukocytes than did pigs fed the basal diet. On d 21following weaning, the percentage of CD14+MHCII+leukocytes isolated from lamina propria tissue tended(P < 0.10) to be lower when pigs were fed mannansthan when pigs were fed the basal diet. Pigs fed dietscontaining mannans had a lower (P < 0.05) ratio ofCD3+CD4+:CD3+CD8+ T lymphocytes isolated from je-junal lamina propria tissue only on d 21 after weaningcomparedwith pigs fed the basal diet. Supplementationof mannans in the diets of weanling pigs improved gainand efficiency, and intermittently affected selected com-ponents of the young pigs’ immune function both sys-temically and enterically.
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