Rapid development in nanotechnology engenders a variety of nanoparticles with novel bio-active ingredients delivered into cancer cells. Natural and synthetic polymers as well as inorganic materials could be used for constructing functional nanoparticles. Among these materials, silica and chitosan have received more attention because of their abundance in nature. Chitosan is a cationic polysaccharide with attractive chemical and biological characteristics for pharmaceutical purposes and has been incorporated into various carrier systems for drug delivery to improve their absorption and targeting characteristics