Administration of HBV immunoglobulin and
HBV vaccine to the children of women positive for
HBV surface antigen (HBsAg) to prevent viral transmission can effectively block MTCT of HBV during
delivery and post-partum. However, passive-active
immunoprophylaxis failure and breakthrough HBV
infections are two unsolved issues for newborns with
HBV intrauterine infection [2-4]. Effective control of
HBV infections should focus on preventing perinatal
transmission of the virus .