10Noise exposure induces the expression of pro-inflammatory cytokines, including tumor necrosis factor-(TNF-), interleukin 1 (IL-1) and interleukin-6 (IL-6).11So et al.12observed a transient up-regulation of IL-6 incisplatin-treated animal models. Wakabayashi et al.13investigated the effect of IL-6 inhibition using an anti-IL-6(MR16-1) antibody in mice. These authors found that MR16-1 showed a protective effect against noise-in ducedcochlear injury, mainly due to neuronal loss suppressionand presumably by relieving the inflammatory response,similar data were found by Nakamoto et al Theseauthors suggested that the suppression of proinflammatorycytokine HSF-1 in the cochlea by the administration of GGA(geranyl---geranyl---acetone) could be an important way toprotect the inner ear