Furthermore, 2 animals on the dose response curve
had greater than anticipated concentrations (greater
than 1.5 SD from the average, with each animal included
in the average). The first outlier, within the 125
mg/L group, used approximately 12 L of water within
1 d. The second outlier did not exhibit any measurable
difference in BW, water consumption, or other factors
that explain the high plasma concentrations. Exclusion
of both animals increases the coefficient of determination
for mean concentrations at steady-state from 0.75
to 0.91 for the dose-response relationship.