Hyperlipidemia, by introducing turbidity, can be a source
of interference that also is method-dependent. Interference
could be due to a variety of mechanisms, such as inhomogeneity of the sample, displacement of water, and adsorption
of lipophilic constituents. A visibly hyperlipidemic sample
can be expected to interfere with the measurement of total
protein and electrophoretic and chromatographic procedures.