basically twofold. Firstly, we perform the analysis on synthetic data, namely a
three-dimensional swissroll which was also used in [1] and [8]. By this phan-
tom data set we illustrate the dierence between both techniques. Secondly, we
analyze a complex, medical real-world data set acquired using dynamic contrast-
enhanced magnetic resonance imaging (DCE-MRI). DCE-MRI involves the re-
peated imaging of a region of interest, in our case the female breast with tumor
lesions, after the administration of a contrast agent, yielding a high-dimensional
spatio-temporal data structure.