FIG. 2. Summary diagram relating to the
synthesis of prostaglandins (PG). Points in
the pathway at which there is published
evidence that PG synthesis can be regulated
by polyunsaturated fatty acids (PUFAs) are
indicated. #1 ¼ PUFA composition in
membrane phospholipids, which is affected
by diet. #2 ¼ release of PUFAs from
phospholipids by phospholipase A2. #3 ¼
metabolism of PUFA by PTGS1 or 2 to
generate short-lived PGH. #4 ¼ metabolism
of PGH to active PGE via membrane
prostaglandin E synthase (PTGES).