HF mice had increased plasma insulin concentrations compared
with LF mice (P , 0.05; Table 2) and HFE mice had
reduced plasma insulin compared with HF mice (61% reduction;
Table 2). HOMA-IR calculations (using the final blood glucose
and insulin concentrations) showed that theHFdiet increased the
HOMA-IR index compared with LF mice (P , 0.05; Table 2),
whereas HFE mice exhibited a 76% decrease compared with HF
mice (P , 0.05; Table 2).